8.6.79 - Released: 2025-04-16 - Content: 273841 cells
Morphology File (Standardized)
Morphology File (Original)
Log File (Standardized)
Log File (Original)



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NeuroMorpho.Org ID :  NMO_282236
Cell Name :  Aged_Met_10_1_Glia
Archive Name :  Kodali_Shetty
Species Name :  mouse
Strain :  C57BL/6J
Structural Domains :  Processes, Soma
Physical Integrity :  Processes Moderate
Morphological Attributes :  No Diameter, 2D, Angles
Min Age :  18.0 months
Max Age :  18.0 months
Gender :  Male
Min Weight :  38.8 grams
Max Weight :  45.8 grams
Development :  old
Primary Brain Region :  hippocampus
Secondary Brain Region :  CA3
Tertiary Brain Region :  stratum radiatum
Primary Cell Class :  Glia
Secondary Cell Class :  microglia
Tertiary Cell Class :  Iba1-positive
Original Format :  Neurolucida.dat
Experiment Protocol :  in vitro
Experimental Condition :  Metformin
Staining Method :  immunostaining
Slicing Direction :  coronal
Slice Thickness :  30  μm
Tissue Shrinkage :  Not reported
Objective Type :  oil
Magnification :  100x
Reconstruction Method :  Neurolucida
Date of Deposition :  2022-07-12
Date of Upload :  2024-03-19
Persistence Vector :  Aged_Met_10_1_Glia.pvec
Note :  This reconstruction was obtained from a mouse that received Metformin via oral gavage (100 mg/kg/day in 0.5 ml distilled water; once daily, 5 days/week) for 10 weeks.

Reference Article
Related Article Reference :  Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus.

Measurements
Soma Surface :  430.27 μm2
Number of Stems :  4
Number of Bifurcations :  13
Number of Branches :  30
Overall Width :  49.33 μm
Overall Height :  47.34 μm
Overall Depth :  0.1 μm
Average Diameter :  0.09 μm
Total Length :  204.18 μm
Total Surface :  57.73 μm2
Total Volume :  1.3 μm3
Max Euclidean Distance :  40.6 μm
Max Path Distance :  43.45 μm
Max Branch Order :  6
Average Contraction :  0.94
Total Fragmentation :  69
Partition Asymmetry :  0.69
Average Rall's Ratio :  2
Average Bifurcation Angle Local :  98.16°
Average Bifurcation Angle Remote :  99.66°
Fractal Dimension :  1.03

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